The knowledge of the Creator is not just knowing about Him but understanding our total dependence on Him. It is appreciating His character. It is drawing near to Him for the purpose of intimate, personal relationship with Him.
The reality is that a person who does not desire the HolySpirit does not know Him as Christ Jesus, the Creator. He is altogether lovely, giving and loving. He is desirable beyond anything or anyone in existence.
Anyone who does not desire the HolySpirit will be rejected by the LordJesusChrist because they are unfit for His presence.