See He Be Re Do.
No one really knows anything until they come to the Knowledge Of The Truth - Jesus Christ.
All science and philosophy and religion are man's attempt to understand existence. Every one of those attempts fall short. They come up with explanations or theories that eventually get supplanted by further investigation and thought.
It is in the revelation of God Himself by manifesting Himself and speaking directly to us that we begin to understand the nature of God and therefore ourselves.
It is in the impartation of His Spirit to us that we KNOW in whom we have believed 2Ti 1:12 and reach the point of being at peace which nothing can disturb Phi 4:7.
The Holy Spirit Of Christ Jesus is the Spirit Of Truth.
Many people know about Jesus. Some even know what He said and did. But knowledge about Christ Jesus is not the knowledge of the Truth that this verse is speaking of.
Knowledge of the Truth comes by faith in the Word of the Lord concerning Jesus. That faith produces Eternal Life in the believer on the authority of the Lord`s Word Rom 10:17 Rom 10:10.
In the secular realm, knowledge is the end all. Disciplines are contrived in which knowledge is pursued. However, without the correct assumptions, a discipline or thread of knowledge is merely an intellectual game having no connection at all to Truth.
The acknowledgement of the Creator must be assumption number one. Otherwise, the pursuit is the pursuit of a fool. Pro 1:7 Pro 9:10 Psm 14:1 Psm 53:1 Rom 1:21